Loss of Purkinje Cells is Associated with Demyelination in Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Loss of purkinje cells is associated with demyelination in multiple sclerosis.
disease of the central nervous system (CNS) previously thought to involve mainly the white matter. In the past 10-15 years, pathology and MRI studies have shown that in addition to white matter lesions, there is significant involvement of the gray matter as well as significant axonal and neuronal loss1. Involvement of the cerebellar cortex is not commonly described in MS, although in a recent r...
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The traditional notion that multiple sclerosis is a primary demyelinating disease has led to a plaque-centred view of both aetiology and the pathogenesis of disease progression. The presence of axonal loss has received increasing recognition. However, the relative roles of demyelination and axonal loss have not been fully clarified in multiple sclerosis nor have their possible interrelationship...
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Tuberous sclerosis complex (TSC) is a dominant tumor suppressor disorder caused by mutations in either TSC1 or TSC2. TSC causes substantial neuropathology, often leading to autism spectrum disorders (ASDs) in up to 60% of patients. The anatomic and neurophysiologic links between these two disorders are not well understood. We have generated and characterized a novel TSC mouse model with Purkinj...
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Cerebellar ataxia commonly occurs in multiple sclerosis, particularly in chronic progressive disease. Previous reports have highlighted both white matter and grey matter pathological changes within the cerebellum; and demyelination and inflammatory cell infiltrates appear commonly. As Purkinje cell axons are the sole output of the cerebellar cortex, understanding pathologic processes within the...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 2011
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100012014